I need help creating a thesis and an outline on Pathophysiology of the Microcirculation. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. All the pulmonary arteries have much larger diameters than their counterparts in the systemic circulation (Guyton 1986). These vessels are also thin and distensible, giving them large compliance (Guyton 1986). This compliance allows the pulmonary arteries to accommodate most of the stroke volume output of the right ventricle (Guyton 1986). The blood flow through the lungs is essentially equal to the cardiac output (Guyton, 1986).
The arterioles act as control valves through which blood is released into the capillaries (Guyton, 1986). The function of the capillaries is to exchange fluid, nutrients, electrolytes and other substances between the blood and the interstitial spaces (Guyton, 1986). The venules collect blood from the capillaries and gradually coalesce into larger veins (Guyton 1986.)
Resistance can be defined as the “impediment to blood flow in a blood vessel” (Guyton 1986, p.260). In case the blood vessels throughout the body are strongly constricted, the total peripheral resistance increases, and conversely, when the blood vessels are greatly dilated, it decreases (Guyton 1986.)
Cardiac output can be defined as “the quantity of blood pumped into the aorta each minute by the heart”(Guyton 1986, p. 272). Under normal circumstances, the major factor determining the cardiac output is the rate of venous return (Guyton 1986.)
The abnormal AV anastomoses, which have developed throughout the body due to the drug Proshibar, can be considered as greatly dilated veins, which hold large quantities of blood. Therefore, the total peripheral resistance would be very low. A low peripheral resistance would lead to a fall in systemic blood pressure. The body will naturally try to raise systemic blood pressure by compensatory mechanisms. These compensatory mechanisms include the nervous pressure control mechanisms and the renin-angiotensin system (RAS).