T h e n e w e ng l a n d j o u r na l o f m e dic i n e
Original Article
Dexamethasone in Hospitalized Patients
with Covid-19 — Preliminary Report
The RECOVERY Collaborative Group*
A BS T R AC T
BACKGROUND
Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce
progression to respiratory failure and death.
METHODS
In this controlled, open-label trial comparing a range of possible treatments in
patients who were hospitalized with Covid-19, we randomly assigned patients to
receive oral or intravenous dexamethasone (at a dose of 6 mg once daily) for up to
10 days or to receive usual care alone. The primary outcome was 28-day mortality.
Here, we report the preliminary results of this comparison.
RESULTS
A total of 2104 patients were assigned to receive dexamethasone and 4321 to receive usual care. Overall, 482 patients (22.9%) in the dexamethasone group and
1110 patients (25.7%) in the usual care group died within 28 days after randomization (age-adjusted rate ratio, 0.83; 95% confidence interval [CI], 0.75 to 0.93;
P
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