s anemia- This is a pathological condition associated with a decrease in the number of erythrocytes due to the insufficiency of vitamin B12, which in turn results in the reduced production of erythrocytes.
How do malabsorptive disorders contribute to the development of anemias- Malabsorption disorders are also involved in the pathogenesis of anemia due to decrease or faulty production of red blood cells. An example is Iron deficiency anemia, whereby disruption of absorption in the duodenum may lead to a decrease in hemoglobin production as this mineral is necessary for this procedure. This in turn will result in decreased Hb levels and anemia. Abosorbtive disorders may also disrupt the uptake of folate and vitamin B12 which are both necessary for erythropoiesis.
What is “anemia of chronic disease”- Anemia of chronic disease refers to any long term disease leading to inflammatory, malignant or infectious processes that reduce both erythropoietin and Iron levels. In addition these diseases reduce the lifespan of erythrocytes. Examples of such pathologies include severe trauma, rheumatoid arthritis, diabetes mellitus and heart disease.
What are some of the lab tests used to evaluate anemia of chronic disease- Lab tests used to evaluate anemia of chronic disease include Iron panel, serum folic acid and vitamin B12, serum AST and ALT, levels of TSH, electrophoretic studies of urine and serum and serum levels of metals such as arsenic and lead.
1. Iron deficiency anemia-This is anemia due to faulty or decreased erythropiesis. The body has insufficient Iron, hence cannot synthesize hemoglobin. This anemia is often normocytic or microcytic and is also hypochromic. Symptoms include pallor, fatigue, loss appetite, irritability.
2. B-12 deficiency- This leads to megaloblastic anemia. And is often associated with loss of gastric cells unlike Iron deficiency which involves disorders of the duodenum. T